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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Saudagar, Ravindra B.
- Analgesic and Antiinflammatory Activity of Amarwel Extracts on Experimentally Induce Pain and Inflammation on Animals
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Materials and Methods: Petroleum ether extract, methanol extract, and aqueous extracts of Cuscuta reflexa (PECR, MECR, and AECR respectively) at three dose levels of 50, 200 and300 mg/kg body weight of an animal by oral route were used for biological activities. The analgesic activity of was determined using hot plate analgesia, acetic acidinduced writhing response and formalin test. The anti-inflammatory activity of was determined using models like carrageenan, serotonin and histamine-induced paw edema models along with cotton pellet induced granuloma. Probable mechanism involved in the antiinflammatory effect of methanol and aqueous extracts was evaluated with various tests like ulcerogenicity test; acetic acid induced vascular permeability test, and leukocyte migration test using a single dose of 300 mg/kg orally.
Results: The HPTLC analysis showed presence of quercetin in MECR and AECR (0.121 and 0.071 mg% respectively). Acute oral toxicity test revealed the LD50 of >2 g/kg. PECR, MECR and AECR (200 and 300 mg/kg p.o.) significantly (P<0.05) increased latency against thermal stimulus, decreased the acetic acid-induced writhing responses and licking times of the second phase in the formalin test. Moreover, MECR and AECR (200 and 300 mg/kg p.o.) exhibited significant (P<0.01) antiinflammatory effect against carrageenan and mediator-induced paw edema.
Conclusion: Results suggest significant analgesic and anti-inflammatory effects produced by MECR and AECR.
Authors
Affiliations
1 KCTS R. G. Sapkal College of Pharmacy, A/p-Anjaneri, Tal-Trimbakeshwar, Dist-Nashik, Maharashtra, IN
2 Bhujbal Knowledge City, MET's Institute of Pharmacy, Adgaon, Nashik, Maharashtra, IN
3 KCT'S RGS College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
4 SNJB's SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik, Maharashtra, IN
1 KCTS R. G. Sapkal College of Pharmacy, A/p-Anjaneri, Tal-Trimbakeshwar, Dist-Nashik, Maharashtra, IN
2 Bhujbal Knowledge City, MET's Institute of Pharmacy, Adgaon, Nashik, Maharashtra, IN
3 KCT'S RGS College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
4 SNJB's SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik, Maharashtra, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 6, No 2 (2014), Pagination: 112-117Abstract
Objective: To study Analgesic and anti-inflammatory activity of Amarwel extracts on experimentally induce pain and inflammation on animalsMaterials and Methods: Petroleum ether extract, methanol extract, and aqueous extracts of Cuscuta reflexa (PECR, MECR, and AECR respectively) at three dose levels of 50, 200 and300 mg/kg body weight of an animal by oral route were used for biological activities. The analgesic activity of was determined using hot plate analgesia, acetic acidinduced writhing response and formalin test. The anti-inflammatory activity of was determined using models like carrageenan, serotonin and histamine-induced paw edema models along with cotton pellet induced granuloma. Probable mechanism involved in the antiinflammatory effect of methanol and aqueous extracts was evaluated with various tests like ulcerogenicity test; acetic acid induced vascular permeability test, and leukocyte migration test using a single dose of 300 mg/kg orally.
Results: The HPTLC analysis showed presence of quercetin in MECR and AECR (0.121 and 0.071 mg% respectively). Acute oral toxicity test revealed the LD50 of >2 g/kg. PECR, MECR and AECR (200 and 300 mg/kg p.o.) significantly (P<0.05) increased latency against thermal stimulus, decreased the acetic acid-induced writhing responses and licking times of the second phase in the formalin test. Moreover, MECR and AECR (200 and 300 mg/kg p.o.) exhibited significant (P<0.01) antiinflammatory effect against carrageenan and mediator-induced paw edema.
Conclusion: Results suggest significant analgesic and anti-inflammatory effects produced by MECR and AECR.
Keywords
Dodder, Hot Plate, Writhing, Formalin Test, Carrageenan, Granuloma, Quercetin.
References
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- Calixto JB, Beirith A, Ferreira J, Santos AR, Cechinel FV, Yunes RA. Naturally occurring antinociceptive substances from plants. Phytother Res. 14; 2000: 401-418.
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- Udavant, PB, Satyanarayana SV, Upasani CD. In vitro anthelmintic activity of stems of Cuscuta reflexa. International Journal of Bioassays. 01 (08),;2012: 18-19.
- Suresh V, Sruthi V, Padmaja B, Asha VV. In vitro anti inflammatory and anti-cancer activities ofCuscuta reflexa Roxb. J Ethnopharmacol.134, 2011: 872-887.
- Udavant, PB, Satyanarayana SV, Upasani CD. Preliminary Screening of Cuscuta Reflexa stems for anti-inflammatory and cytotoxic activities. Asian Pac J Trop biomed, 2012: S1304- S1306.
- Evans WC.. Trease and Evan's Pharmacognosy, 13th ed. Balliere Tindal, London,1989: 419-420.
- Chang C, Yang M, Wen H, Chern J. Estimation of total flavonoids content in propolis by two complementary colorimetric methods. Journal of Food and Drug Analysis. 10;2002: 178-182.
- Hahn DH, Rooney LW, Earp, CF. Tannins and phenols of sorghum. Cereal Foods World, 29;1984:76-779.
- Iwueke AV, Nwodo AFC, Okili CO. Evaluation of the anti-inflammatory and analgesic activities ofVitex doniana leaves. Afr J Biotechnol. 5 (20);2006: 1929-1935.
- Eddy NB, Leimbach D. Synthetic analgesics: Dithienylbutenyl and dithienylbutylamines. J Pharmacol Exp Ther. 107;1953: 385–393.
- Vasudevan M, Gunnam KK, Parle M. Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract. J Ethnopharmacol. 109;2007: 264-270.
- Lu TC, Ko YZ, Huang HW, Hung YC, Lin YC, Peng WH. Analgesic and antiinflammatory activities of aqueous extract from Glycine tomentella ischolar_main in mice. J Ethnopharmacol. 113;2007: 142-148.
- Winter CA, Risley EA, Nuss CW. Carrageenan-induced oedema in hind paw of the rat as an assay for anti-inflammatory drugs. In, Proceedings of the Society for Experimental Biology and Medicine, 111;1962: 544-547.
- Parmar NS, Ghosh MN. Antiinflammatory activity of Gossypin, a biflavonoid isolated from Hibiscus Vitifolius. Indian J Pharmacol.10 (4);1978: 277-293.
- Winter CA, Porter CC. Effect of alterations in the side chain upon anti-inflammatory and liver glycogen activities of hidrocortisone esters. J Am Pharm Assoc. 46;1957: 515-519.
- Okili CO, Akah PA. Mechanisms of the anti-inflammatory activity of the leaf extracts of Culcasia scandens P, Beauv (Araceae). Pharmacol, Biochem Behav. 79;2004: 473-481.
- Okili CO, Akah PA, Nwafor SV, Anisiobi AI, Ibegbunam IN, Erojikwe O. Anti-inflammatory activity of hexane leaf extract of Aspilia Africana. J Ethnopharmacol. 109;2007: 219-225.
- Amresh G, Reddy GD, Rao CV, Singh PN. (2007). Evaluation of anti-inflammatory activity of Cissampelos pareira ischolar_main in rats. J Ethnopharmacol. 110;207: 526-531.
- Ribeiro RA, Flores CA, Cunha FQ, Ferreira SH. IL-8 causes in vivo neutrophil migration by a cell dependent mechanism. Immunology. 73;1991: 472-477.
- Choi EM, Hwang JK. Investigations of anti-inflammatory and antinociceptive activities ofPiper cubeba, Physalis angulata and Rosa hybrid. J Ethnopharmacol. 89;2003:171-175.
- Ishola I O, Akindele AJ, Adeyemi OO. Analgesic and anti-inflammatory activities of Cnestis ferruginea Vahl ex DC (Connaraceae) methanol ischolar_main extract. J Ethnopharmacol. 135;2011: 55-62.
- Tjolsen, A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test, an evaluation of the method. Pain.51;1992: 5-17.
- Imam MZ, Nahar N, Akter S, Rana MS. Antinociceptive activity of methanol extract of flowers of Impatiens balsamina. J Ethnopharmacol. 142;2012: 804-810.
- Suleyman H, Mshvildadze V, Gepdiremen A, Elias R. Acute and chronic anti-inflammatory profile of the ivy plant, Hedera helix, in rats. Phytomedicine.10;2003: 370-374.
- Moura ACA, Silva ELF, Fraga MCA, Wanderley AG, Afiatpour P. Anti-inflammatory and chronic toxicity study of the leaves of Ageratum conyzoides L, in rats. Phytomedicine, 12;2005: 138- 142.
- Recent Approaches in Floating Drug Delivery System
Abstract Views :216 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 3 (2016), Pagination: 141-147Abstract
The oral drug delivery systems exhibit variable and short gastric emptying time, which result in incomplete drug release from the delivery system. This leads to diminished efficacy of administered dose. Floating drug delivery system (FDDS) can retain the dosage form in the gastric region for several hrs. Designing the Floating drug delivery system for prolong gastric retention helps in improving bioavailability and improve solubility of the drug that are less soluble in a high pH environment. FDDS applicable for drugs having poor bioavailability because of narrow absorption window in the GIT. FDDS increase the bioavailability of drug by retains the dosage form at the site of absorption. This review mainly focus on information on the basis o their design, classification, advantages, evaluation and future scope of FDDS.Keywords
Floating Drug Delivery System, Gastric Residence Time, Swelling Index, Buoyancy.- Mucoadhesive Formulations for Buccal Mucosa
Abstract Views :210 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
1 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 3 (2016), Pagination: 146-152Abstract
Mucoadhesion could be a field of current interest within the style of drug delivery systems. Mucoadhesive drug delivery system prolongs the continuance of the indefinite quantity kind at the positioning of application or absorption associate degreed facilitates an intimate contact of the indefinite quantity kind with the underline absorption surface and so contributes to improved and higher therapeutic performance of the drug. In recent years several such mucoadhesive drug delivery systems are developed for oral, buccal, nasal, body part and canal routes for each general and native effects.
Issues like high first-pass metabolism and drug degradation within the canal surroundings is circumvented by administering the drug via the buccal route. Moreover, speedy onset of action is achieved relative to the oral route and therefore the formulation is removed if medical care is needed to be out of print. It’s additionally attainable to administer medication to patients UN agency unconscious and fewer co-operative. To forestall accidental swallowing of medicine adhesive tissue layer indefinite quantity forms were advised for oral delivery, including adhesive tablets, adhesive gels, adhesive patches and plenty of alternative indefinite quantity forms with numerous combos of polymers, absorption enhancers. Additionally to the current, studies are conducted on the event of controlled or slow unharness delivery systems for general and native medical care of diseases.
Keywords
Buccal Region, Mucoadhesive, 1st Pass Metabolism.- Fast Dissolving Sublingual Film
Abstract Views :196 |
PDF Views:1
Authors
Affiliations
1 Department of Quality Assurance Technique, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
1 Department of Quality Assurance Technique, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 3 (2016), Pagination: 153-160Abstract
Orally fast dissolving films are an emerging technology with fast onset of activity and improved patient compliance. It enhances the viability of API's and gives better medication use. These formulations are suitable for cold, allergy rhinitis, asthma attacks, CNS issue where fast onset of activity is needed for quicker help. The sublingual course of medication organization is extremely compelling following the medication retained through the sublingual veins by passes hepatic first pass metabolic procedure and also gives a better bioavailability. The present article outlines the definition viewpoints, manufacturing methods like solvent casting method, evaluation parameters and applications of fast dissolving films by sublingual route It has been estimated that approximately 84% of all sales of the top selling commercially available products are delivered via the oral route. Thin film drug delivery has come forward as an advanced alternative to the traditional tablets, capsules and liquids frequently associated with prescription and OTC medications. Similar in size, shape, and thickness to a postage stamp, thin film strips are classically designed for oral administration, with the user placing the strip on or under the tongue(sublingual)or along the inside of the cheeks(buccal).These drug delivery options allows the medication to bypass the first pass metabolism thereby making the medication further available. As the strip dissolves, the drug can enter the blood stream enterically, buccally or sublingually. The permeation is superior with sublingual than buccal than palatal region.Keywords
Fast Dissolving Drug Delivery, Oral Strips, Sublingual Film, Mouth Dissolve.- Formulation Development and Comparative Study of Clopidogrel Bisulfate Matrix Formulations
Abstract Views :194 |
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Authors
Affiliations
1 Department of Pharmaceutics, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
1 Department of Pharmaceutics, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 3 (2016), Pagination: 167-176Abstract
The objective of this study was to design matrix tablets for oral sustained release of clopidogrel bisulfate and to investigate the sustained release behavior of the matrix tablets. Matrices were prepared by direct compression technique, melt method and microencapsulation using sodium carboxymethylcellulose, carnuba wax and ethyl cellulose as a release retardant. The FT-IR analysis indicated the stability and compatibility of drug with excipients. The formulation was optimized on the basis of acceptable tablet properties and invitro drug release. The resulting formulations produced tablets with optimum hardness, uniform thickness, consistent weight uniformity and low friability. The results of dissolution studies indicated that formulations F2 batch exhibited good drug release pattern to provide sufficient concentration for achieving satisfactory therapeutic value for extended period of time. The drug release from F2 formulation was sustained upto 12 hrs. Tablet Fitting in-vitro drug release data from optimized matrix formulation to Korsmeyer Pappas model equation indicated that diffusion and erosion could be mechanism of drug release. Matrix tablet F2 showed no change in physical appearance, drug content after storage 40°C, 75% RH for 3 months.Keywords
Matrix Tablet, Release Retardant, Diffusion, Clopidogrel Bisulfate.- Dendrimer:A Review
Abstract Views :205 |
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Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 3 (2016), Pagination: 188-192Abstract
Dendrimers are a interesting class of synthetic macromolecules having highly branched, three dimensional, nanoscale architecture with very low polydispersity and high functionality. These features have made their application in nanotechnology, pharmaceutical and medicinal chemistry particularly attractive. This review article is focused on different synthetic strategies used in dendrimer synthesis at commercial and laboratory scale. These synthetic strategies includes their own advantages and disadvantages. This review will cover divergent (from core to surface) and convergent (from surface to core) approaches used in dendrimer synthesis and the problems associated with these synthetic strategies. This article also covers the important applications of dendrimers in the field of pharmaceutical sciences. This data of review is collected from various articles, research papers and patents available on dendrimers.- A Novel Approach towards Nanosuspension
Abstract Views :311 |
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Authors
Affiliations
1 Department of Quality Assurance Techniques, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
1 Department of Quality Assurance Techniques, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 4 (2015), Pagination: 186-194Abstract
Many of the newly invented drugs are poorly soluble and they create major problems during formulation and shows poor bioavailability. The problem is even more complex for drugs which belong to BCS class 2 category. To overcome these problems nanotechnology is used to improve the solubility as well as bioavailability of poorly soluble drugs. The reduction of drug particles into submicron range leads to a significant increase in dissolution rate and therefore enhances bioavailability. Nanosuspension contains submicron colloidal dispersion of the pharmaceutical active ingredient particles in a liquid phase stabilized by surfactant. Nanosuspension can be prepared by using stabilizers, organic solvents and other additives such as buffers, salts, polyols, osmogent and cryoprotectant. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes. Nanosuspensions not only solves the problem of poor solubility and bioavailability but also alter the pharmacokinetics of the drug and thus improving safety and efficacy. This review article mainly focuses on preparation of nanolsuspensions by various techniques with their advantages and disadvantages, formulation consideration, characterization and their applications in drug delivery.Keywords
Nanosuspension, Bioavailability, Solubility, Nanotechnology, Poorly Soluble Drugs, Drug Delivery.- Medicated Chewing Gum is an Excellent Drug Delivery System for Self Medication
Abstract Views :182 |
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Authors
Affiliations
1 Department of Pharmaceutics, KCT'S R. G. Sapkal College of Pharmacy, Anjaneri, Dist. Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjaneri, Dist.Nashik- 422212, Maharashtra, IN
1 Department of Pharmaceutics, KCT'S R. G. Sapkal College of Pharmacy, Anjaneri, Dist. Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjaneri, Dist.Nashik- 422212, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 1 (2016), Pagination: 24-30Abstract
Chewing gum has been used for centuries to clean the mouth or refresh the breath. Chewing gum was patented for first time on filed in 1869 and the first medicated chewing gum was commercially made available 1928. In 1991 The European Pharmacopoeia defines medicated chewing gum as ''solid, single-dose preparations with a base consisting mainly of gum that are intended to be chewed but not swallowed''. Chewing gum is an excellent drug delivery system for self-medication as it is convenient and can be administered discretely without water or any other liquid. Basics of the gum formulation, quality control tests, regulatory and safety issues have been addressed to ensure desired therapeutic effects. The release of a drug from chewing gum is dependent upon its water solubility. Water soluble substances are released rapidly and completely from chewing gum and methods are available which retard their release from chewing gum to provide an extended release profile. Slightly water soluble drugs are released slowly and incompletely from chewing gum and require special formulation techniques to produce a satisfactory release profile.Keywords
Medicated Chewing Gum, Oral Drug Delivery, Buccal Drug Delivery, Increased Release, Elastomer.- A Review on Self- Micro Emulsifying Drug Delivery System: Evident to Improve the Oral Bioavailability of Hydrophobic Drugs
Abstract Views :325 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjaneri, Dist.Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjaneri, Dist.Nashik- 422212, Maharashtra, IN
1 Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjaneri, Dist.Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjaneri, Dist.Nashik- 422212, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 2 (2016), Pagination: 131-134Abstract
The SMEDDS are the isotropic mixture of oil, surfactant and co-surfactant. SMEDDS solve the problem of all BCS class of drug such as solubility, high molecular weight, pre systemic first pass effect, enzymatic degradation, gastric irritation and also increase the bioavailability and stability of drug. Currently a number of technologies are available to deal with the poor solubility, dissolution rate and bioavailability of insoluble drugs one of them is Self‐Micro Emulsifying Drug Delivery Systems (SMEDDS). lipid based formulations, selfmicroemulsifying formulations (droplet size <100 nm) are evident to improve the oral bioavailability of hydrophobic drugs primarily due to their efficiency in facilitating solubilization and in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented.Keywords
SMEDDS, Hydrophobic Drugs, Surfactant, Oil, Co-Surfactant, Bioavailability.- Synthesis of Novel Protein Tyrosine Phosphatases 1b inhibitors 2, 5-Disubstituted Oxadiazole
Abstract Views :187 |
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Authors
Affiliations
1 KCT’S RGS College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 SNJB’s SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik, Maharashtra, IN
1 KCT’S RGS College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 SNJB’s SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 4, No 2 (2014), Pagination: 43-49Abstract
Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of tyrosine-phosphorylated proteins and are negative regulators of tyrosine kinase receptor mediated signaling. PTP1B directly interacts with both the IR and IGF- 1R. The importance of PTP1B inhepatic metabolism has been demonstrated in vivo and incellular models. Mice lacking the ptpn1 gene exhibit increased insulin sensitivity owing to enhanced phosphorylation of IR in liver and skeletal muscle, resistance to weight gain on a high-fat diet, and an increased basal metabolic rate. So it is a potential therapeutic target for insulin resistance associated with obesity and type 2 diabetes. To date, studies of PTP-1Bhave been limited by the availability of specific antagonists. Here we investigate a series of 2, 5-disubstituted oxadiazole as novel PTP1B inhibitor. We synthesized few compounds from 2, 5-disubstituted oxadiazole series and screened for the PTP1B inhibition. Compound 9exhibited significant inhibitory activity against PTP1B. Compound 9 showed IC50 value of 0.46 μmol/L and favorable pharmacodynamics properties in mouse. Structure-activity relationships were explained with the help of molecular modeling approach.Keywords
PTP 1 B, Diabetes, 2, 5-Disubstituted Oxadiazole Phosphotyrosine.- Formulation and Evaluation of Controlled Release Matrix Tablet of Albuterol Sulphate
Abstract Views :194 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 4 (2016), Pagination: 223-229Abstract
A sustained release matrix formulation for Albuterol Sulphate was designed and developed to achieve a 12 h release profile. Using HPMC K15M and HPMC K100M as an inert matrix forming agent to control the release of Albuterol Sulphate. The matrix tablets for these formulations were prepared by direct compression and their in-vitro release tests were carried out for a period of 12 hours using USP dissolution test apparatus (type II Paddle) at 37±0.5°C and 50 rpm speed. A 32 full factorial design was used for optimization by taking the concentration of HPMC K15M (X1) and HPMC K100M (X2) were selected as independent variables, whereas initial release at the (Y1, % drug release), (Y2, % drug Content) the concentration of Were chosen as dependent variables. The optimized formulation F9 follows Higuchi model and Korsemeyer - Pappas release kinetics with non- Fickian diffusion mechanism. From the study, it was concluded that the release of Albuterol Sulphate can be effectively controlled using combination of HPMC K15M, HPMC K 100M and Carbopol 940.Keywords
Albuterol Sulphate, Gelucire43/01, Melt Method, Direct Compression Method, Factorial Design.- UV Spectrophotometric Method Development and Validation of Fluticasone Propionate
Abstract Views :178 |
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Authors
Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 2 (2016), Pagination: 135-138Abstract
Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. Simple, precise and accurate UV spectroscopic method has been developed and validated for estimation of Fluticasone propionate. It is a selective agonist at the glucocorticoid receptor. UV spectroscopic method which is based on measurement of absorption of UV light, the spectra of Fluticasone propionate in methanol showed maximum wavelength at 236nm and calibration curve were plotted over the concentrations ranging from 2-22ug/ml of Fluticasone propionate with correlation coefficient 0.9812 validation was performed as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The proposed method was validated.- A Review on-Controlled-Porosity Osmotic Pump Tablet
Abstract Views :324 |
PDF Views:13
Authors
Affiliations
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
1 Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 2 (2016), Pagination: 101-106Abstract
Conventional oral drug delivery systems supply continues release of drug, which cannot release of the drug and effective concentration at the target site. Drug can be delivered in a controlled manner over a long period of time by the process of osmosis. Osmotic devices are the most promising technique for controlled drug delivery. Osmotic drug delivery system is one among the controlled drug delivery employed orally and also as an implantable devices. Various patents available for osmotic drug delivery system like Rose-Nelson pump, Higuchi leeper pump, Higuchi Theeuwes pump, Elementary Osmotic pump etc. various techniques available for preparation of Osmotic Drug Delivery System include Push pull osmotic pump, Osmotic bursting osmotic pump, Liquid oral osmotic system, Sandwiched osmotic tablets, monolithic osmotic system and Controlled porosity osmotic pump. The present review is concerned with the study of drug release system which are tablets coated with walls of controlled porosity. When these system are exposed to water, low levels of water soluble additives is leached from polymeric material i.e. semi permeable membrane and drug releases in a controlled manner over an extended period of time. Drug delivery from this system is not influenced by the different physiological factors within the gut lumen and the release characteristics can be predicted easily from the known properties of the drug and the dosage form. In this paper, various type of osmotically controlled drug delivery systems and mainly the basic components and evaluation parameter of controlled porosity osmotic pump tablets have been discussed briefly.Keywords
Osmotic Pump, Controlled-Porosity Osmotic Pump Tablet, Semi Permeable Membrane, Osmogent, Leachable Pore Formers.- Pharmaceutical Co-Crystallization
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Authors
Affiliations
1 Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
1 Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 1 (2016), Pagination: 51-58Abstract
Co-crystal consists of API and a stoichiometric amount of a pharmaceutically acceptable co-crystal former. Pharmaceutical Co-crystal is non-ionic supramolecular complexes and can be used to address physical property issues such as solubility, stability and bioavailability in pharmaceutical development without changing the chemical composition of the API. Co-crystal is a crystalline entity formed by two different or more molecular entities where the intermolecular interactions are weak forces like hydrogen bonding and π-π stacking. Super porous systems, biodegradable hydrogel systems. Co crystallization alters the molecular interaction and composition of pharmaceutical materials, and is considered better alternative to optimize drug properties. The article gives brief review on the co-crystallization, selection of appropriate co former and preparation of co crystals, different techniques of co-crystallization, physicochemical properties, characterization and applications.Keywords
Pharmaceutical Co-Crystal, Method of Preparation, Characterization of Co-Crystal, and Applications.- Mecaptooxadiazole a Lead Molecule in the Medicinal Chemistry: A Review
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS -413736, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S, IN
3 Department of Pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, IN
4 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS -413736, IN
2 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S, IN
3 Department of Pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, IN
4 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 4 (2011), Pagination: 93-96Abstract
Mercaptooxadiazole is a five membered heterocyclic system consists of two nitrogen and one oxygen atoms along with acidic thiol group. As it increases the acidity of the titled compounds. It can be easily synthesized from hydazides using potassium hydroxide in presence of carbon disulphide. Mercaptooxadiazoles posses wide spectrum of biological activities like antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present review is an attempt made to reveal the therapeutic and synthetic profiles of the mercaptooxadiazole ring.Keywords
Mercaptooxadiazole, Synthesis, Biological Evaluation.- In- Situ Nasal Gel Drug Delivery: An Overview
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 1 (2016), Pagination: 9-14Abstract
Intranasal Therapy has been an accepted form of treatment in the Ayurvedic system of Indian medicine. The nasal delivery is a feasible alternative to oral or parenteral administration for some drug because of the high permeability of the nasal epithelium , rapid drug absorption across this membrane and avoidance of first pass metabolism. Prolonged drug delivery can be achieved by various new dosage forms like in situ gel. In situ forming polymeric formulation are drug delivery system that is in sol form before administration in the body , but once administered , undergoes gelation in situ to form a gel. In situ nasal drug delivery system is the type of mucoadhesive drug delivery system. In situ nasal gel drug delivery system is advantageous over the conventional drug delivery system like sustained and prolonged release of drug , reduced frequency of administration. Thus this review focuses on nasal drug delivery, various aspects of nasal anatomy and physiology, nasal absorption mechanism, and In- situ nasal gel evaluation.Keywords
Nasal Drug Delivery, Nasal In-Situ Gel, Mucoadhesive Drug Delivery System.- Design and Development of Liquisolid Compact of Carvedilol
Abstract Views :197 |
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Authors
Affiliations
1 Department of Pharmaceutics, R. G. Sapkal, College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Chemistry, R. G. Sapkal, College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Pharmaceutics, R. G. Sapkal, College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Chemistry, R. G. Sapkal, College of Pharmacy, Anjaneri, Nashik, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 4 (2015), Pagination: 243-255Abstract
It is suggested here that liquisolid technique has the potential to be optimized for the reduction of drug dissolution rate and thereby production of sustained release systems is possible. In the present study, carvedilol was dispersed in polyethylene glycol 400 as the liquid vehicle. Then a binary mixture of carrier-coating materials ((Avicel PH-102) as the carrier and silica200 as the coating material) was added to the liquid medication under continuous mixing in a mortar. The final mixture was compressed using the tablet compression machine. The effect of drug concentration, loading factor, thermal treating and on release profile of carvedilol from liquisolid compacts were investigated. The release rate of carvedilol from liquisolid compacts was compared to the release of carvedilol from matrix tablets. X-ray crystallography and DSC were used to investigate the formation of any complex between drug and excipients or any crystallinity changes during the manufacturing process. carvedilol tablets prepared by liquisolid technique showed greater retardation properties in comparison with matrix tablets. This investigation provided evidence that (HPMC) hydroxypropyl methylcellulose has important role in sustaining the release of drug from liquisolid tablets. The results also showed that wet granulation had remarkable impact on release rate of carvedilol from liquisolid compacts, reducing the release rate of drug from liquisolid compacts. The results showed that aging (liquisolid tablets were kept at 400C and 75 % relative humidity for 3 months) had no effect on hardness and dissolution profile of drug. The kinetics studies revealed that most of the liquisolid formulations followed the zero-order release pattern. Infrared spectroscopy and DSC ruled out any changes in crystallinity or complex formation during the manufacturing process of liquisolid formulations.Keywords
Carvedilol, Dissolution Rate, Liquisolid Compacts, Sustained Release.- Pharmacological and Synthetic Profile of 1, 2, 4-Triazoles
Abstract Views :212 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS-413736, IN
2 Department of Pharmaceutical Chemistry, R.G.Sapkal College of Pharmacy, Nashik, M.S., IN
3 Department of pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, IN
4 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni, MS-413736, IN
2 Department of Pharmaceutical Chemistry, R.G.Sapkal College of Pharmacy, Nashik, M.S., IN
3 Department of pharmaceutical Chemistry, S.N.D. College of Pharmacy, Yeola, Dist-Nashik, MS, IN
4 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 12 (2011), Pagination: 1807-1811Abstract
Triazole is a five membered heterocyclic system consisting of two carbon atoms and three nitrogen atoms shows wide range of biological activities. Triazoles can be synthesized using Einhorn-Brunner reaction or the Pellizzari reaction from acyl hydrazides. Triazoles posses wide spectrum of biological activities like including antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present reviews attempted to gather the various developments in synthesis and biological activities of triazole derivatives.Keywords
1, 2, 4-Triazole, Pharmacological Activity, SAR, Total Synthesis.- UV Spectrophotometric Method Development and Validation of Benazepril Hydrochloride
Abstract Views :225 |
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Authors
Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 8 (2016), Pagination: 369-372Abstract
Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. Simple, precise and accurate UV spectroscopic method has been developed and validated for estimation of Benazepril Hydrochloride. It is a angiotensin converting enzyme inhibitors. UV spectroscopic method which is based on measurement of absorption of UV light, the spectra of Benazepril Hydrochloride in methanol showed maximum wavelength at 237 nm and calibration curve were plotted over the concentrations ranging from 2-22ug/ml of Benazepril Hydrochloride with correlation coefficient 0.961 validation was performed as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The proposed method was validated.Keywords
Benazepril Hydrochloride, Methanol, Water, Co-Solvency Method, Spectrophotometer and Validation.- Sharpless Asymmetrical Epoxidation:An Overview
Abstract Views :209 |
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Authors
Affiliations
1 Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
1 Department of Pharmaceutics, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT'S R.G. Sapkal College of Pharmacy, Anjenari, Dist. Nashik-422212, Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 6 (2016), Pagination: 281-289Abstract
Sharpless enantioselective epoxidation of achiral primary allyl alcohols is one of the best reaction discovered during the last about three decades. The reaction was typically named after discovery of this by Karl Barry Sharpless. For this discovery Sharpless received the Nobel Prize for medicinal chemistry in the year 2001. This reaction is stearoselective, i.e. it produces only enantionmers as final product. This reaction converts primary and secondary allylic alcohols into the 2, 3 epoxy alcohols. The final enantionmers which is formed will be a stereoselective depending upon the catalyst used during the same reaction. This reactions turns to be industry beneficial due to its applicability and high yield of products in the reaction.Keywords
Sharpless Epoxidation, 2, 3 Epoxy Alcohols, Application of Reaction, Industrial Examples.- SERM’s in Treatment of Breast Cancer
Abstract Views :197 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni-413736, MS, IN
3 Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, MS, IN
4 Department of Pharmaceutical Chemistry, College of Pharmacy, Chincholi, MS, IN
5 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN
1 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., IN
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni-413736, MS, IN
3 Department of Pharmaceutical Chemistry, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, MS, IN
4 Department of Pharmaceutical Chemistry, College of Pharmacy, Chincholi, MS, IN
5 Department of Pharmaceutical Sciences and Research, Bhagwant University, Ajmer, Rajasthan, IN
Source
Asian Journal of Pharmaceutical Research, Vol 1, No 4 (2011), Pagination: 81-86Abstract
Selective estrogen receptor modulators are the class of a chemical compounds acting on a estrogen receptors. These are selectively inhibit or stimulate the estrogen like actions in various tissues. SERMs play a key role in breast cancer chemoprevention. These agents antagonize estrogens in some tissues and mimic their action in others. The mechanism for tissue selectivity appears to be related to differences in their molecular and three-dimensional structures, which affect the transcriptional activity of the activated estrogen receptor. For example, tamoxifen and toremifene act as estrogen antagonists in breast tissue and as estrogen agonists in the endometrium. The present review article is directed towards highlighting the importance of SERMs in treatment of breast cancer.Keywords
Selective Estrogen Receptor Modulators (SERM’s), Breast Cancer, Hormone Replacement Therapy (HRT).- Simultaneous Spectrophotometric Determination of Linagliptin and Metformin Hydrochloride in Combined Tablet Dosage Form
Abstract Views :330 |
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Authors
Affiliations
1 Department of Quality Assurance, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik (Dt), IN
2 Department of Pharmaceutics , R.G. Sapkal College of Pharmacy, Anjaneri, Nasik (Dt), IN
3 Department of Pharmaceutical Sciences, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik (Dt), IN
1 Department of Quality Assurance, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik (Dt), IN
2 Department of Pharmaceutics , R.G. Sapkal College of Pharmacy, Anjaneri, Nasik (Dt), IN
3 Department of Pharmaceutical Sciences, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik (Dt), IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 7, No 2 (2017), Pagination: 79-83Abstract
Simple, precise and economical UV Spectrophotometric methods have been developed for the simultaneous estimation of Linagliptin and Metformin in bulk and pharmaceutical dosage forms. The simultaneous equation (Vierodt's Method), which is based on measurement of absorption at 227nm and 232nm i.e. λmax of Linagliptin and Metformin respectively. Linearity was observed in the concentration range of 1-11μg/ml for Linagliptin and 3-13 μg/ml. The accuracy of methods was assessed by recovery studies and was found to be withinrange of 98- 99% for both Linagliptin and Metformin.The developed methods were validated with respect tolinearity, accuracy (recovery), and precision. The method can be employed for estimation of pharmaceuticalformulations with no interference from any other excipients and diluents. The results were validated statistically as per ICH Q2 R1 guidelines and were found to be satisfactory.Keywords
Linagliptin, Metformin Hydrochloride, ICH, UV-Spectroscopic, Accuracy, Precision.- Development of Naratriptan Hydrochloride In-Situ Nasal Gel
Abstract Views :183 |
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Authors
Nikita S. Malekar
1,
Sheetal B. Gondkar
1,
Bhushan A. Bhairav
1,
Pinak S. Paralkar
2,
Ravindra B. Saudagar
3
Affiliations
1 Department of Quality Assurance Techniques, KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutics , KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, KCT’S, Ravindra Gambhirrao College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
1 Department of Quality Assurance Techniques, KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Pharmaceutics , KCT’S, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, KCT’S, Ravindra Gambhirrao College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN